Figure 6. The C-terminal part of the CIC protein is absent from the truncated protein encoded by CIC::DUX4 fusion transcript 1. (A) The amino acid sequence of the missing part corresponds to amino acids 1506-1608 in CIC/NP_055940.3. The intrinsically disordered region containing 30 P (in bold) and 15 A amino acid residues is in gray background. The serine in the PSPP motif, which can be phosphorylated, is in red and underlined. (B). The phylogenetically conserved peptide CLQLKIREVRQKIMQ in various species. (C) Conservation of the intrinsically disordered region in mammals. *above serine in the PSPP motif.
