Table 5.

Effect size of GGT/HDL-C on incident DM2 in prespecified and exploratory subgroups

Character	Number of participant	Effect size (95%CI)	P value	P for interaction
Age (years)				0.7182
< 60	14,741	1.00 (1.00, 1.01)	0.0903
>  = 60	712	1.00 (0.98, 1.02)	0.9106
Sex				0.9279
Male	8419	1.005 (0.983, 1.027)	0.6853
Female	7034	1.006 (1.000, 1.011)	0.0455*
BMI (kg/m2)				0.6066
< 23	10,059	1.004 (0.996, 1.012)	0.3575
>  = 23	5394	1.006 (1.000, 1.012)	0.0375*
SBP (mmHg)				0.4241
< 140	14,668	1.00 (1.00, 1.01)	0.1285
>  = 140	785	1.01 (1.00, 1.03)	0.1511
DBP (mmHg)				0.3525
< 90	14,690	1.00 (1.00, 1.01)	0.1642
>  = 90	763	1.01 (1.00, 1.02)	0.0866
Current smoker				0.7553
Never	9027	1.00 (0.99, 1.02)	0.3915
Past	2949	1.01 (1.00, 1.02)	0.1355
Current	3477	1.00 (0.99, 1.01)	0.4486
Drinking status				0.5413
Non	11,802	1.00 (1.00, 1.01)	0.2545
Light	1754	1.00 (0.99, 1.02)	0.5992
Moderate	1357	1.00 (0.98, 1.01)	0.6772
Heavy	540	1.02 (1.00, 1.03)	0.0150*
Fatty liver				0.4586
No	12,716	1.00 (1.00, 1.01)	0.4310
Yes	2737	1.007 (1.001, 1.014)	0.0290*
Exercise				0.3589
No	12,747	1.004 (0.998, 1.010)	0.1552
Yes	2706	1.012 (0.997, 1.027)	0.1164

Note 1: Above model adjusted for age, sex, BMI, SBP, DBP, FPG, ALT, AST, HBA1C, TC, TG, fatty liver, smoking and drinking status, exercise status

Note 2: In each case, the model is not adjusted for the stratification variable