Table 1.

Summary of NOC2L roles in biological events

NOC2L-associated molecules	Direct effect by NOC2L	Biological events
P53	P53 acetylation↓  → P53 activity↓	Apoptosis inhibition Cell-cycle arrest inhibition
MDM2	P53 ubiquitination↑  → P53 activity↓
Aurora B	P53 phosphorylation↑  →P53 activity↓
P63	P63-occupied histone acetylation↓  → P63-denpendent transcription↓	Apoptosis inhibition Cell-cycle arrest inhibition Cell division dysfunction
RB	RB acetylation↓  → RB activity↓	Breast cancer proliferation
EZH2	EZH2-occupied histone acetylation↓  → FOXO3 transcription↓	Colorectal cancer proliferation