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. 2023 Jan 12;16(5):dmm049742. doi: 10.1242/dmm.049742

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© 2023. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Fig. 4. — Changes in markers of EBD, cytokines and SCFAs between the CPB/DHCA group and controls. (A) A significant increase was seen in FABP2, claudin-2 and claudin-3 levels between the pre-operative and post-operative samples in the CPB group compared to controls. (B) A significant increase was seen in IL-1β, IL-6 and TNF-α levels between the pre-operative and post-operative samples in the CPB/DHCA group compared to controls. (C) A significant reduction was seen in acetic acid, butyric acid and propionic acid levels between the pre-operative and post-operative samples in the CPB group compared to controls. Two-way ANOVA with Holm–Sidak's multiple comparisons test was performed. FABP2, fatty acid-binding protein 2; IL, interleukin; TNF, tumor necrosis factor. ns, not significant; *P<0.05; **P<0.01; ****P<0.0001.