Fig 1.

Non-linear association derived using restricted cubic splines of individuals from the Copenhagen General Population Study followed for a mean 9.4 years, from Johannesen et al.³⁴ Multivariable adjusted hazard ratios for all cause mortality are shown according to levels of low density lipoprotein cholesterol (LDL-C) on a continuous scale. 95% confidence intervals are derived from restricted cubic spline regressions with three knots. Reference lines for no association are shown at a hazard ratio of 1.0. Arrows indicate concentration of LDL-C associated with the lowest risk of all cause mortality. Analyses were adjusted for baseline age, sex, current smoking, cumulative number of cigarette pack years, systolic blood pressure, lipid lowering treatment, diabetes, cardiovascular disease, cancer, and chronic obstructive pulmonary disease