Figure 1. snRNA-seq profiling of the postnatal human hippocampus across ages.
(A) A schematic of experimental design. HIPP: hippocampus; QC: quality control; Adoles.: adolescent.
(B-C) Uniform Manifold Approximation and Projection (UMAP) of integrated data of cross-age analysis, colored by cell type (B). Cell clusters identified by known marker genes, depicted in violin plots in (C). OPC: oligodendrocyte precursor cells.
(D) Heatmap showing transcriptomic correspondence of major cell types between published datasets of various brain regions and ours using a random forest classifier (Shekhar et al., 2016). PFC: prefrontal cortex; ACC: anterior cingulate cortex.