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. 2022 Dec 22;8(1):5. doi: 10.3390/biomimetics8010005

Table 1.

Biomedical applications of silk-based cryogels.

Composition Type of Silk Application Evaluation Stage Reference
SF
SF		 Silk fibroin Tissue engineering In vitro [66]
Silk fibroin Liver tissue engineering In vitro [22]
SF Silk fibroin Tissue engineering In vitro [67]
SF Silk fibroin Drug delivery In vitro [68]
SF Silk fibroin Drug delivery/Tissue engineering In vivo [69]
SF Silk fibroin Regeneration of annulus fibrosus/
Drug delivery		 In vivo [70]
SF Silk fibroin in situ tissue engineering In vivo [71]
SSF Silk nanofiber Tissue engineering/Drug delivery In vivo [14]
SF/PVA Silk fibroin Regeneration of nucleus pulposus In vitro [57]
SF/PVA Silk fibroin Cartilage tissue engineering In vivo [72]
CANFs@SF/CS Silk fibroin Muscle tissue engineering In vitro [61]
AgSrHA@SF/CS Silk fibroin Bone tissue engineering In vivo [73]
SF/CS/AR/BG/HA Silk fibroin Bone tissue engineering In vivo [58]
laponite@SF Silk fibroin Bone tissue engineering In vivo [74]
SF/GS/GM Silk fibroin Burn healing In vivo [75]
PDA@SF/CS Silk fibroin Healing of full-thickness wounds In vivo [60]
TA/Fe3+@SF/CS Silk fibroin Traumatic hemorrhage/Wound healing In vivo [59]
SMC@Ag Silk sericin Traumatic hemorrhage/Wound healing In vivo [76]
laminin@Gel/SS Silk sericin Cell delivery Healing of diabetic ulcer In vivo [77]
laminin@Gel/SS Silk sericin Cell delivery/Cardiac repair In vivo [78]

SF: Silk fibroin; SSF: short silk nanofiber; PVA: Poly (vinyl) alcohol; CANFs: cellulose acetate electrospun nanofibers; AgSrHA: silver and strontium co-doped hydroxyapatite; AR: Agarose; BG: Bioactive glass; HA: Hydroxyapatite; GS: Gentamycin sulfate; GM: Gelatin microspheres; PDA: polydopamine; CS: Chitosan; TA/Fe3+: tannic acid/ferric ion; SMC@Ag: sericin-methacryloyl/silver; Gel: Gelatin; SS: Silk sericin.