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. Author manuscript; available in PMC: 2024 Jan 1.
Published in final edited form as: Gastroenterology. 2022 Oct 6;164(1):117–133.e7. doi: 10.1053/j.gastro.2022.09.028

Figure 5.

Figure 5.

(A) A summary of imaging findings, preoperative PancreaSeq testing, and postoperative clinicopathologic features of 87 PanNET patients. Both solid and cystic PanNETs exhibited similar genomic alterations; however, LOH for multiple genes correlated with several adverse clinicopathologic features, such as lymphovascular invasion, perineural invasion, higher T- and N-stage, distant metastases, loss of ATRX/DAXX expression, and the presence of ALT. (B) A representative example of a 1.5-cm PanNET (white arrowhead) in the pancreatic body that preoperative PancreaSeq testing revealed LOH for 4 genes. (C) Microscopically and immunohistochemically, the PanNET was classified as WHO grade 1. (D) However, within a single regional lymph node, a metastasis was identified (black arrowhead). In addition, the PanNET exhibited loss of ATRX expression and the presence of ALT. (C) Hematoxylin and eosin stain, magnification 400×. (D) Hematoxylin and eosin stain, magnification 200×.