TABLE 4.

Univariable and Multivariable Associated With Noninvasive Progression

	Univariable HR (95% CI)	P	Multivariable HR (95% CI)	P
Age at surgery	1.01 (0.99–1.03)	0.14	–
Male sex	0.73 (0.50–1.08)	0.13	–
Acute pancreatitis	1.11 (0.64–1.91)	0.72	–
Jaundice	0.33 (0.05–2.37)	0.27	–
Diabetes	0.86 (0.49–1.52)	0.61	–
Family history of pancreatic cancer	2.43 (1.55–3.82)	< 0.001	1.75 (1.05–2.91)	0.03
Delayed surgery ≥6 mo	1.70 (1.14–2.54)	0.009	1.44 (0.94–2.22)	0.09
Smoking
Never	Ref		Ref
Current/past	1.51 (1.03–2.20)	0.04	1.51 (1.00–2.33)	0.05
Cyst > 3 cm	0.98 (0.67–1.45)	0.94	–
Type of cyst
Branch duct	Ref
Main duct	0.70 (0.37–1.35)	0.29	–
Mixed duct	0.85 (0.56–1.30)	0.46	–
Multifocal cysts	1.68 (1.13 –2.52)	0.01	1.54 (1.02–2.34)	0.04
Dilated main pancreatic duct	0.97 (0.66–1.42)	0.87	–
MPD ≥ 5 mm	0.68 (0.45–1.02)	0.06	–
MPD ≥ 10 mm	0.70 (0.34–1.46)	0.34	–
Mural nodule/solid component	1.11 (0.71–1.73)	0.66	–
CA19-9 > 37	1.27 (0.52–3.14)	0.60	–
Positive margin	1.57 (1.00–2.34)	0.05	–
Grade of dysplasia/invasive cancer
Low-intermediate	Ref
High	0.89 (0.57–1.38)	0.60	–

CA 19-9 indicates carbohydrate antigen 19-9; MPD, main pancreatic duct.