TABLE 2.
Meta‐analysis results of ADRs
| Outcomes | Trials | Experimental group (Events/Total) | Control l group (Events/Total) | SM | RR,95% CI | I 2 (%) | p | PB |
|---|---|---|---|---|---|---|---|---|
| Myelosuppression | 9 | 81/302 | 121/300 | FEM | 0.67 (0.54, 0.82) | 0 | <0.0001 | No |
| Gastrointestinal reaction | 8 | 81/288 | 121/286 | REM | 0.75 (0.50, 1.14) | 90 | 0.18 | Unclear |
| Anemia | 5 | 49/217 | 71/213 | FEM | 0.69 (0.52, 0.92) | 0 | 0.012 | Unclear |
| Thrombocytopenia | 10 | 70/431 | 92/428 | FEM | 0.76 (0.58, 0.99) | 0 | 0.0409 | No |
| Liver/Renal dysfunction | 11 | 52/446 | 83/442 | REM | 0.64 (0.47, 0.86) | 0 | 0.0025 | No |
| Neurotoxicity | 13 | 94/432 | 119/429 | FEM | 0.79 (0.64, 0.98) | 0 | 0.0344 | No |
| Nausea/vomiting | 12 | 111/447 | 169/443 | REM | 0.67 (0.50, 0.88) | 58 | 0.0049 | Yes |
| Neutropenia | 3 | 53/139 | 77/133 | FEM | 0.67 (0.54, 0.85) | 25 | 0.0006 | Unclear |
| Hand‐foot syndrome | 8 | 64/281 | 90/276 | REM | 0.62 (0.23, 1.67) | 93 | 0.3449 | Unclear |
| Diarrhea | 12 | 93/452 | 151/443 | FEM | 0.61 (0.49, 0.74) | 0 | <0.0001 | No |
| Leukopenia | 11 | 133/435 | 189/432 | FEM | 0.70 (0.60, 0.82) | 32 | <0.0001 | Yes |
| Hematological toxicity | 3 | 40/88 | 53/88 | REM | 0.62 (0.09, 4.26) | 97 | 0.6244 | Unclear |
Note: Forest of all results are in Figure S1.
Abbreviations: CI, confidence interval; FEM, fixed‐effects model; PB, Publication bias; REM, random‐effects model; RR, relative ratio; SM, statistical method.