TABLE 1.

Effect of teicoplanin on the TFA of monocytes incubated with S. aureus or staphylococcal constituents

Treatmenta	Mean fold increase in FXa formation ± SDb:
	Without teicoplanin	With teicoplaninc
None	1B	1.25 ± 0.02D
S. aureus	1.59 ± 0.36A	1.65 ± 0.22C
Supernatantd	1.13 ± 0.20	1.63 ± 0.35C

^a1.5 × 10⁶ monocytes were incubated for 4 h on noninfected or infected fibrin plates, and then the TFA was determined as described in the text. 

^bThat is, the fold increase of FXa formation over that of monocytes cultured on noninfected fibrin plates in the absence of teicoplanin. These cells had a TFA of 33.6 ± 8.7 pmol of FXa/10⁶ monocytes. P values (superscript letters): A versus B, P < 0.05; C versus D, P < 0.05. 

^cSupernatants were collected from S. aureus cultures grown for 5 h at 37°C in BHI broth, after which 10 μg of teicoplanin per ml was added to the medium, and bacteria were then cultured for an additional 20 h. 

^dSupernatant of S. aureus, cultured in the presence or absence of 10 μg of teicoplanin per ml. Supernatants, diluted 1 to 10 with RPMI, were added to monocytes that were cultured for 4 h on fibrin plates.