TABLE 2.
Effect of S. aureus 5558 infection and teicoplanin treatment on TFA, infection, and weight of rabbit endocardial vegetationsa
| Treatment | Infection (log CFU/g of vegetation) | TFA (pmol of FXa/g of vegetation) | Wt (mg) |
|---|---|---|---|
| Sterile | 116 ± 23D | 11.19 ± 5.07H | |
| S. aureus | >10A | 119 ± 6E | 44.26 ± 14.21J |
| S. aureus plus 2× teicoplaninb | 8.63 ± 0.59B | 157 ± 17F | 30.80 ± 11.07K |
| S. aureus plus 4× teicoplaninb | 7.27 ± 0.50C | 85 ± 4G | 36.63 ± 7.90L |
a
Endocarditis was induced as described in the text. All values represent the mean ± the SD of four rabbits. P values (superscript letters): A versus B, P = 0.004; A versus C, P < 0.001; B versus C, P = 0.005; D versus E, P > 0.05; E versus F, P = 0.032; F versus G, P < 0.001; H versus J, P = 0.002; J versus K, P > 0.05; J versus L, P > 0.05.
b
Teicoplanin treatment started 24 h after injection of staphylococci and was given at 24-h intervals.