TABLE 6.
Association between the selected SNPs and lung cancer, stratified by average age
| SNP | Year | Genotype | Case (%) | Control (%) | OR a (95% CI) | p |
|---|---|---|---|---|---|---|
| rs1948915 | >58 | TT | 109 (28.5) | 90 (26.7) | 1 (REF) | |
| CT | 189 (49.3) | 175 (51.9) | 0.919 (0.642–1.316) | 0.645 | ||
| CC | 85 (22.2) | 72 (21.4) | 1.092 (0.707–1.687) | 0.692 | ||
| CC + CT vs. TT | 274 vs. 109 | 247 vs. 90 | 0.968 (0.689–1.359) | 0.851 | ||
| CC vs. CT + TT | 85 vs. 298 | 72 vs. 265 | 1.153 (0.799–1.666) | 0.446 | ||
| C vs. T | 359 vs. 407 | 319 vs. 355 | 0.982 (0.798–1.208) | 0.861 | ||
| ≤58 | TT | 82 (28.7) | 80 (22.2) | 1 (REF) | ||
| CT | 136 (47.6) | 187 (51.9) | 0.645 (0.428–0.972) | 0.036 | ||
| CC | 68 (23.8) | 93 (25.8) | 0.691 (0.430–1.110) | 0.126 | ||
| CC + CT vs. TT | 204 vs. 82 | 280 vs. 80 | 0.660 (0.449–0.971) | 0.035 | ||
| CC vs. CT + TT | 68 vs. 218 | 93 vs. 267 | 0.925 (0.628–1.362) | 0.692 | ||
| C vs. T | 272 vs. 300 | 373 vs. 347 | 0.843 (0.677–1.051) | 0.129 | ||
| rs7013433 | >58 | TT | 122 (31.9) | 108 (32.0) | 1 (REF) | |
| AT | 180 (47.0) | 166 (49.3) | 1.003 (0.709–1.418) | 0.987 | ||
| AA | 81 (21.1) | 63 (18.7) | 1.286 (0.833–1.985) | 0.257 | ||
| AA + AT vs. TT | 261 vs. 122 | 229 vs. 108 | 1.078 (0.779–1.493) | 0.649 | ||
| AA vs. AT + TT | 81 vs. 302 | 63 vs. 274 | 1.284 (0.877–1.878) | 0.199 | ||
| A vs. T | 342 vs. 424 | 292 vs. 382 | 1.055 (0.857–1.300) | 0.614 | ||
| ≤58 | TT | 92 (32.2) | 95 (26.4) | 1.000 (REF) | ||
| AT | 138 (48.3) | 180 (50.0) | 0.756 (0.512–1.117) | 0.160 | ||
| AA | 56 (19.6) | 85 (23.6) | 0.71 (0.441–1.143) | 0.158 | ||
| AA + AT vs. TT | 194 vs. 92 | 265 vs. 95 | 0.742 (0.513–1.071) | 0.111 | ||
| AA vs. AT + TT | 56 vs. 230 | 85 vs. 275 | 0.846 (0.563–1.273) | 0.422 | ||
| A vs. T | 250 vs. 322 | 350 vs. 370 | 0.821 (0.658–1.023) | 0.079 | ||
| rs6983267 | >58 | TT | 116 (30.3) | 118 (35.0) | 1 (REF) | |
| GT | 200 (52.2) | 175 (51.9) | 1.130 (0.806–1.585) | 0.480 | ||
| GG | 67 (17.5) | 44 (13.1) | 1.603 (0.998–2.576) | 0.051 | ||
| GG + GT vs. TT | 267 vs. 116 | 219 vs. 118 | 1.223 (0.885–1.689) | 0.223 | ||
| GG vs. GT + TT | 67 vs. 316 | 44 vs. 293 | 1.487 (0.971–2.278) | 0.068 | ||
| G vs. T | 334 vs. 432 | 263 vs. 411 | 1.208 (0.979–1.491) | 0.078 | ||
| ≤58 | TT | 115 (40.2) | 122 (33.9) | 1 (REF) | ||
| GT | 137 (47.9) | 170 (47.2) | 0.831 (0.576–1.199) | 0.323 | ||
| GG | 34 (11.9) | 68 (18.9) | 0.505 (0.301–0.849) | 0.010 | ||
| GG + GT vs. TT | 171 vs. 115 | 238 vs. 122 | 0.737 (0.521–1.043) | 0.085 | ||
| GG vs. GT + TT | 34 vs. 252 | 68 vs. 292 | 0.561 (0.349–0.903) | 0.017 | ||
| G vs. T | 205 vs. 367 | 306 vs. 414 | 0.756 (0.603–0.947) | 0.015 |
Abbreviations: CI, confident interval; OR, odds ratio; REF, reference; SNP, single nucleotide polymorphism.
a
OR: adjusted by gender and smoking status.