TABLE 1.
Division rate of intracellular tachyzoites in primary human cells in vitroa
| Cell type | Parasite division rate
|
Mechanism | Reference(s) | |
|---|---|---|---|---|
| Unprimed | IFN-γ primed | |||
| Hemopoietic | ||||
| Lymphocyte | S | ND | This study | |
| Neutrophil | S | ND | This study, 19, 30 | |
| Adherent monocyte | S | ROM; not TS | 5, 9, 15–17, 30 | |
| Nonadherent monocyte | R | R | This study, 9 | |
| Dendritic cell | R | ND | This study | |
| Alveolar macrophage | R | S | Partly TS | 17 |
| Peritoneal macrophage | R | S | ND | 31 |
| Monocyte-derived macrophage | R | S | ROM; not RNM | 1, 5, 16, 17, 31 |
| Nonhemopoietic | ||||
| Neuron | S | ND | 10 | |
| Foreskin fibroblast | R | S | TS | 22, 23 |
| Umbilical vein endothelial cell | R | S | Not RNM, TS, or ROM | 16, 32 |
| Retinal pigment epithelial cell | R | S | TS | 18 |
| Fetal astrocyte | R | S | RNM | 10, 20 |
| Fetal microglial cell | R | R | 4 | |
a
S, slow; R, rapid; ND, not determined; ROM, reactive oxygen metabolites; TS, tryptophan starvation; RNM, reactive nitrogen metabolites.