Table 1.
Effects of Treatments on the Growth of U87 Intracerebral Tumor
| Therapeutic Groups | Number of Days to Reach RTV = 30 | RTV ≥ 30 Reached on D20 | ||
|---|---|---|---|---|
| Median (in Days) | Range | Number of Animals | (Percentage) | |
| Control | 12.9 | [4.5–23.5] | 6/7 | (85.7%) |
| Au@DTDTPA(Gd) NPs | 18.6 | [8–35.5] | 6/8 | (75.0%) |
| RT | 18.4 | [14.5–34.5] | 5/8 | (62.5%) |
| RT + NPs | 25.3 | [21.5–35] | 0/8 | (0.0%) |
Notes: NPs: Mice received intraveneous injection of Au@DTDTPA(Gd) nanoparticles at a dose of 75 mg/kg. RT: 2 fractions of X-rays irradiation at 5 Gy on D0 and D3. RT + NPs: intraveneous injection of Au@DTDTPA(Gd) at 75 mg/kg 5 minutes before the first fraction of irradiation; 2 fractions of 5 Gy on D0 and D3. Based on the determination of tumor volume by intravital microscopy, two criteria were considered: the time (in days) taken for the relative tumor volume (RTV) to reach 30 and the number of mice whose RTV exceeded 30 on day 20 of follow-up.