Table 1. Twenty most significantly upregulated genes at day 1 for HSV529 recipients divided into three groups based on prior exposure to herpes simplex virus (HSV).
Changes in expression compared to day 0 were analyzed using Bioconductor package DESeq2, with log 2 fold changes reported and p values corrected for multiple comparisons. Genes marked in red are present in both HSV1+/HSV2− and HSV1±/HSV2+, but not HSV1−/HSV2− subjects.
| HSV1−/HSV2− | HSV1+/HSV2− | HSV1±/HSV2+ | ||||||
|---|---|---|---|---|---|---|---|---|
| Gene | Fold change | p adjusted | Gene | Fold change | p adjusted | Gene | Fold change | p adjusted |
| MX1 | 1.95 | 7.02 × 10−31 | GBP2 | 1.14 | 1.36 × 10−20 | ANKRD22 | 5.44 | 4.37 × 10−44 |
| EIF2AK2 | 1.28 | 3.99 × 10−28 | GBP1 | 2.06 | 2.60 × 10−19 | GBP5 | 1.94 | 6.39 × 10−41 |
| IFI44 | 2.01 | 3.99 × 10−28 | PSTPIP2 | 0.98 | 4.27 × 10−18 | WARS | 2.19 | 2.03 × 10−40 |
| ISG15 | 2.10 | 3.99 × 10−28 | ANKRD22 | 3.54 | 7.25 × 10−18 | ETV7 | 4.12 | 5.08 × 10−40 |
| IFI6 | 2.26 | 4.94 × 10−28 | FCGR1B | 2.32 | 4.39 × 10−17 | GBP1 | 2.86 | 1.64 × 10−39 |
| HERC5 | 1.66 | 3.52 × 10−27 | WARS | 1.44 | 9.49 × 10−17 | GBP4 | 1.86 | 1.93 × 10−38 |
| OAS3 | 1.95 | 3.52 × 10−27 | GBP4 | 1.24 | 2.28 × 10−16 | IDO1 | 4.02 | 4.50 × 10−38 |
| CMPK2 | 2.12 | 5.75 × 10−27 | LAP3 | 1.54 | 2.28 × 10−16 | CD274 | 1.72 | 2.16 × 10−37 |
| HERC6 | 1.02 | 5.75 × 10−27 | GBP5 | 1.24 | 3.51 × 10−16 | LAP3 | 2.26 | 7.50 × 10−37 |
| IFI44L | 2.68 | 1.52 × 10−26 | GBP1P1 | 3.09 | 5.37 × 10−16 | GBP2 | 1.46 | 1.71 × 10−36 |
| LAMP3 | 1.94 | 2.86 × 10−26 | FCGR1A | 2.05 | 7.64 × 10−16 | GBP1P1 | 4.40 | 6.42 × 10−34 |
| IFIT1 | 2.92 | 1.39 × 10−25 | STAT1 | 1.37 | 1.27 × 10−15 | VAMP5 | 1.63 | 6.16 × 10−33 |
| IFIT2 | 2.41 | 5.10 × 10−25 | APOL4 | 3.12 | 2.45 × 10−15 | CXCL10 | 4.50 | 1.98 × 10−32 |
| SPATS2L | 1.32 | 6.94 × 10−25 | PSME2 | 0.84 | 3.67 × 10−15 | FCGR1B | 3.10 | 1.98 × 10−32 |
| USP18 | 1.89 | 1.30 × 10−24 | FCGR1C | 2.55 | 5.59 × 10−14 | SERPING1 | 3.79 | 2.05 × 10−32 |
| PARP12 | 0.72 | 1.86 × 10−24 | IRF1 | 0.89 | 1.52 × 10−13 | PSME2 | 1.20 | 2.41 × 10−32 |
| RSAD2 | 2.29 | 1.86 × 10−24 | APOL2 | 0.64 | 2.19 × 10−13 | BATF2 | 3.81 | 2.58 × 10−32 |
| TRIM22 | 0.78 | 2.45 × 10−24 | PARP9 | 1.14 | 3.14 × 10−13 | IRF1 | 1.34 | 3.16 × 10−32 |
| HELZ2 | 1.16 | 2.23 × 10−23 | APOL3 | 0.55 | 3.89 × 10−13 | APOL3 | 0.83 | 7.00 × 10−32 |
| MX2 | 1.25 | 5.10 × 10−23 | SAMD4A | 1.24 | 3.89 × 10−13 | SAMD4A | 1.86 | 1.74 × 10−31 |