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. Author manuscript; available in PMC: 2023 Jan 17.
Published in final edited form as: Nature. 2022 Mar 28;605(7909):304–309. doi: 10.1038/s41586-022-04670-9

Extended Data Fig. 3. Neuropathological diagnosis of donors 1–4 as FTLD-TDP.

Extended Data Fig. 3

Immunohistochemistry staining using a phosphor-Ser409/410 TDP-43 antibody was performed for brain sections from donors 1–4. All four donors were confirmed to be FTLD-TDP cases, representing the 4 subtypes A to D, respectively. For all figures, scale bar 20 μm. a, b, c, Donor 1 is FTLD-TDP type C, with long, thick neurites (arrows in b) and “Pick-body like NCI” in dentate fascia (c). d, e, f, Donor 2 is FTLD-TDP type B, displaying characteristic granular cytoplasmic NCI in cortex (d), hippocampus (e) and dentate fascia (f). g, h, i, Donor 3 is FTLD-TDP type A, exhibiting small dense neuronal cytoplasmic inclusions (NCI), sparse neuronal intranuclear inclusions (NII, arrow in g), and perivascular glial inclusions (arrow in h). j, k, l, Donor 4 is FTLD-TDP type D, shown by frequent NII (arrows in j, k and l) and small NCI and neurites. a, b, d, e, g, h, i, j, k, l are brain sections from the temporal cortex. c and f are brain sections from dentate fascia.