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. Author manuscript; available in PMC: 2023 Jan 17.
Published in final edited form as: Nature. 2022 Mar 28;605(7909):304–309. doi: 10.1038/s41586-022-04670-9

Extended Data Fig. 6. Cryo-EM maps of TMEM106B fibrils from FTLD-TDP donors 1 to 4.

Extended Data Fig. 6

The models of PM1–3 from donor 1 were rigid body fitted into the maps of PM1–3 from donors 2 to 4. These cryo-EM structures reveal the polymorphs from all four donors share the same protofilament fold. Two subtypes of PM2 are exhibited by donors 1 and 4 (light green) and donors 2 and 3 (dark green), respectively.