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. Author manuscript; available in PMC: 2023 Jan 17.
Published in final edited form as: ACS Chem Biol. 2021 Jun 4;16(6):1019–1029. doi: 10.1021/acschembio.1c00106

Figure 1: Class I lanthipeptide biosynthesis in Pedobacter lusitanus NL19.

Figure 1:

(A) Schematic overview of (methyl)lanthionine formation by class I lanthipeptide synthases. (B) Ped15 biosynthetic gene cluster and the precursor peptides examined in this study. Red, precursor peptides; Blue, transport; Olive, core biosynthetic machinery; Green, regulatory proteins. N/A no annotation. BGC components visualized using the Gene Graphics web tool.85 Previously identified recognition motif for LahT150 is shown in bold. (C) Sequence conservation of catalytic residues in the core biosynthetic enzymes of the Ped15 biosynthetic gene cluster. Key catalytic residues are highlighted in blue (LanBs) and red (LanC’s) and are labeled according to their proposed mechanistic role.