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. 2023 Jan 17;13(1):e1181. doi: 10.1002/ctm2.1181

FIGURE 8.

FIGURE 8

Differentiation of B cells in a metastatic LN. (A) UMAP plots showed seven subtypes of B cells in LNs by the tissue source type. (B) Bar plots showed the proportions of seven B cell subtypes in LNs in the tissue source types. (C and D) Violin plots showed the expression of Naive gene set in NBCs (C) and ASC gene set in ASCs (D). Significance of these gene set enrichment (p value) between tissue source types was determined by Wilcoxon rank‐sum test. Boxplots included centreline, median; box limits, upper and lower quartiles; whiskers at most 1.5× the interquartile range past upper and lower quartiles. * p < .05, **** p < .0001. (E) UMAP plots showed expression levels of XBP1 and IGHG1 by the tissue source type. Black dotted frames showed B cells except for ASCs. (F) Violin plots showed the expression of the ASC gene set in B cells except for ASCs. Significance of this gene set enrichment (p value) between tissue source types was determined by Wilcoxon rank‐sum test. Boxplots included centreline, median; box limits, upper and lower quartiles; whiskers at most 1.5× the interquartile range past upper and lower quartiles. ns; not significant, **** p < .0001.