Table 1.
Composition of solid dispersion formulations with their responses.
| Formula code | Polymer | Drug: polymer ratio | % Drug content ± SD | Saturated solubility in phosphate buffer (µg/mL) ± SD |
|---|---|---|---|---|
| SD1 | Pluronic F-127 | 1:1 | 96.35 ± 1.75 | 30.17 ± 1.63 |
| SD2 | 1:2 | 97.14 ± 0.95 | 38.73 ± 0.98 | |
| SD3 | 1:3 | 95.87 ± 0.85 | 44.26 ± 1.64 | |
| SD4 | 1:4 | 98.53 ± 1.05 | 54.53 ± 2.05 | |
| SD5 | PEG 4000 | 1:1 | 96.82 ± 2.03 | 22.86 ± 1.96 |
| SD6 | 1:2 | 98.16 ± 1.63 | 29.56 ± 1.73 | |
| SD7 | 1:3 | 99.04 ± 1.87 | 37.27 ± 1.83 | |
| SD8 | 1:4 | 96.15 ± 2.06 | 42.58 ± 0.93 | |
| Pure drug | 14.54 ± 1.58 | |||