Table 2.
Apparent maximal concentration (Cmax), time at which apparent maximal concentration was reached (Tmax), area under the curve (AUC) and apparent half-life of elimination (t1/2) for THC in nasal mucosa, lung, plasma, olfactory bulb and cerebellum of adolescent (PND 31) male and female rats after 30-min aerosol exposure to a THC aerosol (100 mg/mL).
| Tissue | Male | Female | ||||||
|---|---|---|---|---|---|---|---|---|
| Cmax (pmol/mL or g) | AUC (pmol•min/mL or g) | Tmax (min) | t1/2 (min) | Cmax (pmol/mL or g) | AUC (pmol•min/mL or g) | Tmax (min) | t1/2 (min) | |
| Nasal mucosa | 29,998 ± 12,660 | 578,266 ± 230,738 | 5 | 3.9 ± 0.2 | 19,175 ± 293 | 613,129 ± 317,513 | 5 | 3.9 ± 0.0 |
| Lung | 6,881 ± 1,026* | 91,689 ± 18,654* | 5 | 4.4 ± 0.1 | 4,168 ± 502***,## | 51,805 ± 7,543* | 5 | 4.6 ± 0.1 |
| Plasma | 279 ± 17** | 9,148 ± 1,537** | 5 | 8.5 ± 0.5 | 349 ± 38*** | 7,080 ± 1,151* | 5 | 6.9 ± 0.2# |
| Olfactory Bulb | 464 ± 86** | 14,356 ± 3,099** | 5 | 6.3 ± 0.3 | 303 ± 82*** | 10,348 ± 2,261* | 5 | 7.2 ± 0.3 |
| Cerebellum | 331 ± 36** | 16,557 ± 4,935** | 5 | NA | 246 ± 60*** | 11,195 ± 2,781* | 60 | NA |
Data are represented as means ± standard error of the mean, n = 3–4.
*
P < 0.05,
**
P < 0.01,
***
P < 0.001 (significant tissue effect compared to nasal mucosa), one-way ANOVA;
#
P < 0.05,
##
P < 0.01 (significant sex effect), two-way ANOVA.