Table 2.

List of CRISPR editing strategies used in CAR T cell therapy

Purpose of strategy	Targeted proteins	KI/KO via CRISPR	Reference
Generation of allogeneic CART cells	TCR	KO	[78]
	HLA	KO	[78]
Protection from immunosuppression by blocking pre-apoptotic signaling	Fas	KO	[79]
Protection from immunosuppression by knocking out genes	PD-1	KO	[80]
	CTLA-4	KO	[81]
	LAG-3	KO	[82]
	TIM-3	KO	[83]
	DGK	KO	[84]
	A2AR	KO	[85, 86]
	PTPN2	KO	[87]
	TGFβR	KO	[48, 88, 89]
Reduction of CAR T cell associated toxicities	GM-CSF	KO	[90]