Skip to main content
. Author manuscript; available in PMC: 2024 Jan 1.
Published in final edited form as: Pharmacol Res. 2022 Nov 20;187:106560. doi: 10.1016/j.phrs.2022.106560

Figure 1. Morphine, AM1710, and LY2828360 alleviate ddC-evoked mechanical and cold allodynia.

Figure 1.

ddC induces mechanical and cold hypersensitivity. C57Bl6/J mice treated with ddC displayed mechanical (p<0.001 for all time points, A) and cold (p<0.001 for all time points, B) allodynia on days 2-14 following onset of ddC treatments. N=23 per group. Morphine (A, B), AM1710 (C, D), and LY2828360 (E, F) suppress mechanical and cold allodynia induced by ddC treatment without altering responding in C57Bl6/J mice not treated with ddC. ***p<0.001, **p<0.01, *p<0.05 vs. non ddC-treated mice. $$$p<0.001, $$p<0.01 vs. all other groups. Two-way ANOVA followed by Tukey multiple comparisons test post-hoc N= 5-6 per group. BL: baseline, ddC: 2’-3’-dideoxycitidine, LY: LY02828360, MOR: morphine.