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. Author manuscript; available in PMC: 2024 Jan 1.
Published in final edited form as: Pharmacol Res. 2022 Nov 20;187:106560. doi: 10.1016/j.phrs.2022.106560

Figure 10. Removal of CB2 receptors from peripheral sensory neurons eliminates the antinociceptive efficacy of CB2 receptor agonists.

Figure 10.

AM1710 (A,B) and LY2828360 (C,D) dose dependently alleviate ddC-evoked mechanical and cold allodynia in CB2f/f GFP mice, but fail to alter ddC-induced behavioral hypersensitivities in advillinCre/+;CB2f/f mice. The reference analgesics morphine and gabapentin reverse ddC-evoked mechanical (A) and cold (B) hypersensitivity in CB2f/f and advillinCre/+;CB2f/f mice. ###p<0.0001 vs. pre-ddC baseline, **p<0.01, ***p<0.0001 male and female CB2f/f vs. ddC, $$$p<0.0001 all groups vs. ddC. Two-way ANOVA, Tukey multiple comparisons test post-hoc. (N= 5 per group).