AM1710 (10 mg/kg, i.p., A,B), LY2828360 (3 mg/kg i.p., C,D) and morphine (10 mg/kg, i.p., E,F) alleviated ddC evoked mechanical and cold hypersensitivity at comparable levels in male and female C57BlJ/6 mice at 0.5, 2.5 and 4.5 hours post-administration relative to ddC-treated mice receiving vehicle. ###p<0.0001 all groups vs. baseline. ***p<0.0001 vs. veh-treated male and female, $$p<0.01, $p<0.05 vs. female veh, &p<0.05 female AM1710 vs. female veh, ~p<0.05 male MOR vs. female MOR, %%%p<0.001 female MOR vs. female veh. Two-way ANOVA, Tukey multiple comparisons test post-hoc. (N=4 per group).