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. Author manuscript; available in PMC: 2024 Jan 1.
Published in final edited form as: Pharmacol Res. 2022 Nov 20;187:106560. doi: 10.1016/j.phrs.2022.106560

Figure 8. CB2 and GFP mRNA are detectable within nociceptive circuitry.

Figure 8.

CB2 and GFP mRNAs are detectable in tissues implicated in nociceptive processing. CB2 mRNA was present at comparable levels between CB2f/f and wild type C57BlJ/6 mice in the spleen, spinal cord and DRG (A-C). GFP mRNA was detectable in the spleen, spinal cord and DRG of CB2f/f mice (D-F). (N=6 for wildtype group, N=11 for CB2f/f, animals used for this study were age matched between 90 days 150 days. Values were calculated using the 2(−ΔΔCt) method. GAPDH was used as reference gene. In WT tissues, CT values for GFP were typically undefined and assigned an arbitrary CT value of 37 for comparison with values in reporter mice. Data are expressed as mean ± S.E.M. **p < 0.01, ***p<0.001, unpaired sample two tailed t-test.