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. Author manuscript; available in PMC: 2024 Jan 1.
Published in final edited form as: Pharmacol Res. 2022 Nov 20;187:106560. doi: 10.1016/j.phrs.2022.106560

Table 1.

Summary of Statistical Analyses of Data Presented in Figure Panels

Figure Time Drug Interaction
1A mechanical: F1,44 = 386.3, p<0.0001 mechanical: F6,44 = 94.68, p<0.0001 mechanical: F6,44 = 31.26, p<0.0001
1B cold: F1,44 = 541.6, p<0.0001 cold: F6,44 = 121, p<0.0001 cold: F6,44 = 80.17, p<0.0001
1C mechanical: F3,18 = 31.59, p<0.0001 mechanical: F4,18 = 56.66, p<0.0001 mechanical: F12,18 = 11.51, p<0.0001
1D cold: F3,18 = 89.55, p<0.0001 cold: F4,18 = 80.45, p<0.0001 cold: F12,18 = 26.57, p<0.0001
1E mechanical: F3,18 = 57.32, p<0.0001 mechanical: F4,18 = 73.81, p<0.0001 mechanical: F12,18 = 11.45, p<0.0001
1F cold: F3,18 = 79.81, p<0.0001 cold: F4,18 = 60.14, p<0.0001 cold: F4,19 = 63.68, p<0.0001
1G mechanical: F3,19 = 57.44, p<0.0001 mechanical: F4,19 = 73.71, p<0.0001 mechanical: F12,19 = 14.15, p<0.0001
1H cold: F3,19 = 107.9, p<0.0001 cold: F4,19 = 63.68, p<0.0001 cold: F12,19 = 26.22, p<0.0001
Time Drug Interaction
2A mechanical: F2,66 = 439.8, p<0.0001 mechanical: F6,66 = 213.8, p<0.0001 mechanical: F12,66 = 22.75, p<0.0001
2B cold: F6,66 = 480.4, p<0.0001 cold: F6,66 = 418.5, p<0.0001 cold: F12,66 = 83.78, p<0.0001
AM1710 LY2828360 Vehicle
2C mechanical: F3,7=252.5, p<0.0001 mechanical: F3,7=109.1, p<0.0001 Mechanical: F3,6=297.3, p<0.0001
2D cold: F3,7=768.9, p<0.0001 cold: F3,7=814.4, p<0.0001 cold: F3,6=967.8, p<0.0001
Figure Time Drug Interaction
3A mechanical: F5,60 = 186.3, p<0.0001 mechanical: F3,12 = 38.82, p<0.0001 mechanical: F15,60 = 16.54, p<0.0001
3B cold: F5,60 = 296.4, p<0.0001 cold: F3,12 = 117, p<0.0001 cold: F15,60 = 50.94, p<0.0001
3C mechanical: F5,60 = 77.09, p<0.0001 mechanical: F3,12 = 28.09, p<0.0001 mechanical: F15,60 = 8.735, p<0.0001
3D cold: F5,60 = 89.54, p<0.0001 cold: F3,12 = 46.43, p<0.0001 cold: F15,60 = 15.45, p<0.0001
3E mechanical: F5,60 = 123.4, p<0.0001 mechanical: F3,12 = 49.93, p<0.0001 mechanical: F15,60 = 15.48 p<0.0001
3F cold: F5,60 = 138.9, p<0.0001 cold: F3,12 = 87.59, p<0.0001 cold: F15,60 = 25.93, p<0.0001
4A mechanical: F6,72 = 124.6, p<0.0001 mechanical: F3,12 = 108, p<0.0001 mechanical: F18,72 = 15.69, p<0.0001
4B cold: F6,72 = 247.3, p<0.0001 cold: F3,12 = 504.6, p<0.0001 cold: F18,72 = 62.47, p<0.0001
4C mechanical: F6,72 = 86.43, p<0.0001 mechanical: F3,12 = 61.48, p<0.0001 mechanical: F18,72 = 11.13, p<0.0001
4D cold: F6,72 =89.94, p<0.0001 cold: F3,12 = 407.6, p<0.0001 cold: F18,72 = 21.65, p<0.0001
4E mechanical: F6,72 = 274.6, p<0.0001 mechanical: F3,12 =33.51, p<0.0001 mechanical: F18,72 = 18,36, p<0.0001
4F cold: F6,72 = 215.9, p<0.0001 cold: F3,12 = 61, p<0.0001 cold: F18,72 = 24.04, p<0.0001
Figure 5
IL-1β: T5=2.8, p=0.04
TNF-α: T5=3.52, p=0.016
CCL2: T6=2.5, p=0.047
Figure 6
6A F2,8=5.11, p=0.04
6B F2,7=8.07, p=0.02
6C F2,8=4.87, p=0.04
6D F2,8=5.52, p=0.03
6E F2,8=7.05, p=0.02
6F F2,9=2.12, p=0.18
6G F2,9=4.22, p=0.051
6H F2,9=2.86, p=0.12
6I F2,9=3.53, p=0.07
8A T14=1.6, p=0.13
8B T13=1.6, p=0.13
8C T13=2.13, p=0.053
8D T13=4.73, p=0.0004
8E T14=10.17, p<0.0001
8F T12=2.08, p=0.05
9A T13=4.041, p=0.001
9B T14=1.611, p=0.13
9C T13= 0.76, p=0.46
9D T14=0.82, p=0.43
9E T13=3.31, p=0.006
9F T14=1.62, p=0.13
9G T13=0.44, p=0.67
9H T14=2.03, p=0.062
Figure Drug Genotype Interaction
10A mechanical: F7,112 = 245.9, p<0.0001 mechanical: F3,16 = 39.38, p<0.0001 mechanical: F21,112 = 17.2, p<0.0001
10B cold: F7,112 = 384.7, p<0.0001 cold: F3,16 = 46.6, p<0.0001 cold: F21,112 = 37.66, p<0.0001
10C mechanical: F7,112 = 286.5, p<0.0001 mechanical: F3,16 = 71.86, p<0.0001 mechanical: F21,112 = 19.17, p<0.0001
10D cold: F7,112 = 414.9, p<0.0001 cold: F3,16 = 54.81, p<0.0001 cold: F21,112 = 36.35, p<0.0001
Figure Within Between Interaction
11A mechanical: F6,192 = 162.2, p<0.0001 mechanical: F3,32 = 159.2, p<0.0001 mechanical: F18,192 = 32.51, p<0.0001
11B cold: F6,192 = 131.8, p<0.0001 cold: F3,32 = 174.2, p<0.0001 cold: F18,192 = 24.9, p<0.0001
11C mechanical: F6,126 = 243.3, p<0.0001 mechanical: F3,27 = 78.5, p<0.0001 mechanical: F18,162 = 22.11, p<0.0001
11D cold: F6,162 = 212.9, p<0.0001 cold: F3,27 = 139.5, p<0.0001 cold: F18,162 = 20.42, p<0.0001
11E mechanical: F6,168 = 210.6, p<0.0001 mechanical: F3,28 = 52.67, p<0.0001 mechanical: F18,168 = 14.68, p<0.0001
11F cold: F1,168 = 403.3, p<0.0001 cold: F3,28 = 111.4, p<0.0001 cold: F18,168 = 31.51, p<0.0001
11G mechanical: F6,156 = 322.4, p<0.0001 mechanical: F3,26 = 9.351, p<0.001 mechanical: F18,156 = 4.47, p<0.0001
11H cold: F6,156 = 618.3, p<0.0001 cold: F3,26 = 37.18, p<0.0001 cold: F18,156 = 15.85, p<0.0001
Figure Within Between Interaction
12A mechanical: F6,180 = 201, p<0.0001 mechanical: F3,30 = 90.69, p<0.0001 mechanical: F18,180 = 32.5, p<0.0001
12B cold: F6,180 = 147, p<0.0001 cold: F3,30 = 124.5, p<0.0001 cold: F18,180 = 23.47, p<0.0001
12C mechanical: F6,156 = 243.6, p<0.0001 mechanical: F3,26 = 20.89, p<0.0001 mechanical: F18,156 = 20.93, p<0.0001
12D cold: F6,156 = 221.7, p<0.0001 cold: F3,26 = 43.37, p<0.0001 cold: F18,156 = 18.11, p<0.0001
12E mechanical: F6,162 = 178.5, p<0.0001 mechanical: F3,27 = 60.03, p<0.0001 mechanical: F18,162 = 15.06, p<0.0001
12F cold: F6,162 = 362.7, p<0.0001 cold: F3,27 = 96.56, p<0.0001 cold: F18,162 = 29.34, p<0.0001
12G mechanical: F6,156 = 377.4, p<0.0001 mechanical: F3,26 = 6.8, p<0.001 mechanical: F18,156 = 6.281, p<0.0001
12H cold: F6,156 = 617.3, p<0.0001 cold: F3,26 = 26.18, p<0.0001 cold: F18,156 = 14.87, p<0.0001