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. 2023 Jan 17;14:255. doi: 10.1038/s41467-023-35895-5

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — a Schematic representation of photothermal/mechanical synergistic thrombolysis effects in a FeCl₃-induced rat carotid arterial thrombosis model. b Representative fluorescence images (scale bar = 2 mm) and c quantitative results of the carotid artery embolic vessels after intravenous injection of DiR Sol, B-BD NAs, T-BD NAs, or N-BD NAs at an equivalent DiR dose of 5 mg/kg. Data are presented as mean ± SD. Source data are provided as a Source Data file. In vivo photothermal heating curves d and images e of carotid artery thrombotic vessels under 808 nm laser irradiation (2.0 W/cm², 15 min), scale bar = 2 cm. Data are presented as mean ± SD. Source data are provided as a Source Data file. f Nonpharmaceutical thrombolysis rates of carotid arterial vessel sections after various treatments, quantitatively analyzed by software Image-pro plus. Data are presented as mean ± SD. Source data are provided as a Source Data file. One-way ANOVA (one-sided) with Dunnett’s multiple comparisons test was used for the analysis of data and adjusted P value. g Nonpharmaceutical thrombolysis results of carotid arterial vessels sections after various treatments, scale bar = 100 μm. h Schematic diagram of NO-mediated thrombolysis mechanism: antiplatelet aggregation. i The sCD40L levels in the blood samples of rats after various treatments. Data are presented as mean ± SD. Source data are provided as a Source Data file. One-way ANOVA (one-sided) with Dunnett’s multiple comparisons test was used for the analysis of data and adjusted P value. The n.s. represent no significance.