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. 2023 Jan 17;14:255. doi: 10.1038/s41467-023-35895-5

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — a Treatment scheme in ischemic stroke salvage. b Representative tissue fluorescence imaging images of the MCAO model rats (Embolism) and health rats (Sham) after intravenous injection of T-BD NAs and DiR Sol, scale bar = 1 cm. c Fluorescence quantitative results of major organs in the MCAO model rats (Embolism) and health rats (Sham). Data are presented as mean ± SD. Source data are provided as a Source Data file. One-way ANOVA (one-sided) with Dunnett’s multiple comparisons test was used for the analysis of data and adjusted P value. d Brain fluorescence quantitative results of T-BD NAs and DiR Sol in the MCAO model rats (Embolism) and health rats (Sham) after intravenous injection. Data are presented as mean ± SD. Source data are provided as a Source Data file. e Representative photographs of TTC-stained brain slices of Sham group, Embolism group (0.9% NaCl), DiR Sol + L group (2 W/cm², 15 min), and T-BD NAs + L group (2 W/cm², 15 min), the infarct area is observed as white, scale bar = 1 mm. f Brain infarct volumes of the Sham group, Embolism group (0.9% NaCl), DiR Sol + L group (2 W/cm², 15 min) and T-BD NAs + L group (2 W/cm², 15 min), respectively. Data are presented as mean ± SD. Source data are provided as a Source Data file. One-way ANOVA (one-sided) with Dunnett’s multiple comparisons test was used for the analysis of data and adjusted P value. g Representative H&E staining results of the brain tissues in the Sham group, Embolism group (0.9% NaCl), DiR Sol + L group (2 W/cm², 15 min), and T-BD NAs + L group (2 W/cm², 15 min), respectively. h Neurological scores of the rats in the Sham group, Embolism group (0.9% NaCl), DiR Sol + L group (2 W/cm², 15 min), and T-BD NAs + L group (2 W/cm², 15 min), respectively. Data are presented as mean ± SD. Source data are provided as a Source Data file. One-way ANOVA (one-sided) with Dunnett’s multiple comparisons test was used for the analysis of data and adjusted P value.