Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2023 Jan 17;6:15. doi: 10.1038/s42004-022-00809-x

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 6 — a–c Lateral snapshots of the simulated bilayers containing increasing amounts of POPC-OOH. Colour coding: Green-POPC, Gray-oxPOPC9, Purple-oxPOPC10 (see Fig. S15 for details), Yellow-Phosphorous, Red-Oxygen. BC10 is also shown (cyan), within the leaflet regardless of the membrane’s composition, but closer to the phospholipid headgroups in the 100% POPC-OOH membrane. d, f Electron density profiles of membranes containing increasing amounts of POPC-OOH. In (e) the red traces correspond to all lipids (continuous trace), POPC (dotted) and POPC-OOH (dashed). g Area-thickness relationship for lipid peroxide containing bilayers. Data shown as mean ± S.D. from two independent simulations. h Relative variation of the 2-dimensional diffusion coefficient obtained from the MD simulations (⎕) and from molecular rotor data using the Saffman-Delbrück equation (∎). i, j Snapshots of a coarse-grained simulation showing the area per lipid (APL) maps of pure POPC (i) and POPC-OOH (j) membranes. Scalebar: 30 nm. k Bimodal APL distribution seen for the oxidized membranes (j), supporting the observation of lipid segregation in POPC-OOH membranes.