TABLE 3.
Univariate and multivariate Cox proportional hazard analyses of factors associated with overall survival in the training cohort.
| Univariate test | Multivariate test | |||||
|---|---|---|---|---|---|---|
| HR | 95% CI | P-value | HR | 95% CI | P-value | |
| Age, yr | ||||||
| ≤65 | ||||||
| >65 | 1.040 | .563–1.919 | .901 | |||
| Gender | ||||||
| Male | ||||||
| Female | .522 | .278–.978 | .043 | 1.192 | .580–2.446 | .633 |
| BMI, kg/m2 | ||||||
| ≤25.2 | ||||||
| >25.2 | .275 | .121–.625 | .002 | .413 | .175–.971 | .043 |
| Jaundice | ||||||
| No | ||||||
| Yes | 2.853 | 1.521–5.350 | .001 | .512 | .143–1.829 | .303 |
| Gallbladder stone | ||||||
| No | ||||||
| Yes | .853 | .467–1.561 | .607 | |||
| Diabetes mellitus | ||||||
| No | ||||||
| Yes | .727 | .285–1.854 | .505 | |||
| R0 resection | ||||||
| Yes | ||||||
| No | 4.374 | 2.363–8.096 | <.001 | 3.096 | 1.558–6.151 | .001 |
| Tumor differentiation | ||||||
| Moderate-well | ||||||
| Poor | 2.079 | 1.136–3.805 | .018 | .905 | .448–1.829 | .781 |
| TNM stage | ||||||
| 0–II | ||||||
| III–IV | 5.645 | 2.006–15.886 | .001 | 4.921 | 1.631–14.849 | .005 |
| Nevin stage | ||||||
| I–II | ||||||
| III–V | 5.477 | 1.944–15.430 | .001 a | |||
| Tumor size, cm | ||||||
| ≤3 | ||||||
| >3 | 2.369 | 1.204–4.663 | .013 | 1.085 | .487–2.415 | .842 |
| Tumor location | ||||||
| Neck | ||||||
| Body, bottom | .709 | .252–1.994 | .514 | |||
| Tumor number | ||||||
| Single | ||||||
| Multiple | 1.158 | .536–2.501 | .708 | |||
| Intraoperative blood loss, ml | ||||||
| ≤50 | ||||||
| >50 | 3.011 | 1.621–5.595 | <.001 | 1.645 | .711–3.804 | .245 |
| AAPR | ||||||
| ≤.20 | ||||||
| >.20 | .266 | .142–.499 | <.001 | .212 | .060–.757 | .017 |
a
Nevin stage was excluded from the multivariate Cox regression due to the multicollinearity between the TNM, stage and the Nevin stage (VIF >5).
Abbreviations: yr, year; BMI, body mass index; AAPR, albumin to alkaline phosphatase ratio. Indicate statistically significant.