TABLE 4.

Enrichment analysis for DNA regulatory regions.

Group	DNA region	DMP proportion		Odds ratio*	p-value*
		Top DMP’s in MS n = 10,000	All DMP’s n = 788,804
MS versus Control (All)	Enhancer FANTOM5	0.1295	0.0332	3.90	<1e-15
	Enhancer	0.2101	0.1535	1.47	<1e-15
	ENCODE/X450K
	TSS200	0.0216	0.0433	0.49	<1e-15
	TSS1500	0.0393	0.0631	0.61	<1e-15
	Promoter associated	0.0325	0.1298	0.26	<1e-15
	ENCODE
MS versus Control (Black or African American)	Enhancer FANTOM5	0.0915	0.0332	2.94	<1e-15
	Enhancer	0.2000	0.1535	1.38	4.33e-13
	ENCODE/X450K
	TSS200	0.0249	0.0433	0.56	<1e-15
	TSS1500	0.0461	0.0631	0.72	<1e-15
	Promoter associated	0.0362	0.1298	0.25	<1e-15
	ENCODE
MS versus Control (Hispanic or Latino)	Enhancer FANTOM5	0.0766	0.0332	2.42	<1e-15
	Enhancer	0.2053	0.1535	1.42	<1e-15
	ENCODE/X450K
	TSS200	0.0388	0.0433	0.89	0.026
	TSS1500	0.0510	0.0631	0.80	3.78e-07
	Promoter associated	0.0442	0.1298	0.31	<1e-15
	ENCODE

* Fisher’s Exact Test for Count Data.

Abbreviations: TSS, transcriptional start site; DMP, differentially methylated probe; FANTOM5, functional annotations of the mammalian genome, version 5; ENCODE, encyclopedia of DNA, elements.