TABLE 5.
Top 10 differentially methylated regions (DMR) associated with multiple sclerosis.
| DMR | Chromosome | Start | End | #CpGs | FDR (min smoothed) | HMFDR | Max difference M Value (MSvCon) | Mean difference M Value (MSvCon) | Overlapping genes |
|---|---|---|---|---|---|---|---|---|---|
| 1 | chr8 | 27467783 | 27470225 | 14 | 1.20E-136 | 2.43E-07 | −0.05091 | −0.03652 | CLU |
| 2 | chr17 | 27044169 | 27045894 | 21 | 6.15E-111 | 1.79E-05 | −0.06709 | −0.03536 | RAB34 |
| 3 | chr9 | 1.26E+08 | 1.26E+08 | 14 | 1.89E-107 | 9.11E-07 | −0.07037 | −0.0436 | RABGAP1 |
| 4 | chr10 | 63807168 | 63809170 | 17 | 1.50E-94 | 3.11E-06 | 0.056923 | 0.040503 | ARID5B |
| 5 | chr17 | 7460485 | 7462249 | 15 | 8.03E-94 | 3.34E-06 | −0.05216 | −0.02834 | TNFSF12-TNFSF13 |
| 6 | chr12 | 1.24E+08 | 1.24E+08 | 14 | 2.76E-90 | 1.35E-06 | −0.06444 | −0.03567 | CDK2AP1 |
| 7 | chr20 | 57581529 | 57583709 | 27 | 1.91E-89 | 1.58E-05 | −0.0482 | −0.0146 | CTSZ |
| 8 | chr10 | 1.05E+08 | 1.05E+08 | 14 | 8.26E-82 | 8.14E-07 | −0.04491 | −0.02297 | WBP1L |
| 9 | chr4 | 1.55E+08 | 1.55E+08 | 36 | 1.98E-81 | 1.97E-05 | −0.04727 | −0.01471 | SFRP2 |
| 10 | chr2 | 1.6E+08 | 1.6E+08 | 16 | 6.13E-78 | 1.15E-06 | −0.07885 | −0.03049 | BAZ2B |
DMR: differentially methylated region, CpG: 5′-cytosine-phosphate-guanine-3′, FDR: false detection rate, HMFDR: harmonic mean of individual CpG FDR’s.