TABLE 8.
Top 10 differentially methylated regions (DMR) associated with dimethyl fumarate treatment.
| DMR | Chromosome | Start | End | #CpGs | FDR (min smoothed) | HMFDR | Max difference M Value (DMFvOther) | Mean difference M Value (DMFvOther) | Overlapping genes |
|---|---|---|---|---|---|---|---|---|---|
| 1 | chr22 | 44463707 | 44465038 | 10 | 2.57E-64 | 0.001067 | −0.07046 | −0.0306 | PARVB |
| 2 | chr17 | 27044169 | 27045894 | 21 | 2.19E-55 | 0.01804 | −0.07319 | −0.03276 | RAB34 |
| 3 | chr10 | 1.05E+08 | 1.05E+08 | 14 | 5.76E-53 | 0.003279 | −0.04699 | −0.01822 | WBP1L |
| 4 | chr3 | 1.12E+08 | 1.12E+08 | 15 | 1.42E-52 | 0.007249 | −0.04847 | −0.02573 | TAGLN3 |
| 5 | chr22 | 44568203 | 44568812 | 9 | 9.40E-51 | 0.004387 | −0.05 | −0.03259 | PARVG |
| 6 | chr5 | 1.77E+08 | 1.77E+08 | 13 | 2.84E-50 | 0.003224 | −0.04945 | −0.02524 | DOK3 |
| 7 | chr12 | 51403056 | 51403966 | 6 | 5.95E-48 | 0.000422 | −0.05586 | −0.02471 | SLC11A2 |
| 8 | chr7 | 1094263 | 1096387 | 12 | 2.54E-46 | 0.004215 | −0.04168 | −0.02055 | GPR146 |
| 9 | chr8 | 27467783 | 27469673 | 13 | 1.19E-44 | 0.0076 | −0.04168 | −0.02666 | CLU |
| 10 | chr3 | 33700962 | 33701707 | 9 | 2.44E-40 | 0.003399 | −0.03639 | −0.02407 | CLASP2 |
*12 patients on dimethyl fumarate, 8 on glatiramer, 6 on ocrelizumab, 1 on interferon, and 1 on natalizumab.
DMR, differentially methylated region; CpG, 5′-cytosine-phosphate-guanine-3′; FDR, false detection rate; DMF, dimethyl fumarate; HMFDR, harmonic mean of individual CpG FDR’s.