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. 2023 Jan 17;14:252. doi: 10.1038/s41467-023-35880-y

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a The frequency of mutations and homozygous (Homo) deletions in 67 common negatively selected genes from the TCGA Firehose Legacy cohort (Upper panel, n = 492) and the SU2C/PCF cohort (Lower panel, n = 444)^25,26. b Dose-response curves after treatment with olaparib for C4-2B cells with gene knockout (KO) as indicated. Data are presented as mean ± SD (n = 3 biologically independent experiments). The p-values were determined by comparing two gene-specific sgRNAs to a control AAVS1 sgRNA using two-way ANOVA. Source data are provided as a Source Data file.