Table 1.
Details of the instruments used for exposures.
| Exposure | Consortium | Sample size | No. SNPs | I2 | F-statistics | Pleiotropy | Heterogeneity | Population | ||
|---|---|---|---|---|---|---|---|---|---|---|
| Intercept | P value | Q | P value | |||||||
| Educational duration | UK Biobank | 307,897 | 22 | 8.927E−04 | 14.049 | 1.229E−02 | 0.518 | 30.675 | 0.060 | European |
| Educational level | UK Biobank | 458,079 | 237 | 7.216E−03 | 14.042 | − 7.357E−03 | 0.261 | 261.957 | 0.109 | European |
| Intelligence | UK Biobank | 149,051 | 49 | 4.824E−03 | 14.741 | 2.299E−03 | 0.869 | 57.141 | 0.148 | European |
| BMI | UK Biobank | 461,460 | 660 | 2.780E−02 | 19.967 | 1.914E−04 | 0.939 | 755.199 | 0.005 | European |
| LDL-C | UK Biobank | 440,546 | 250 | 1.993E−02 | 35.821 | − 2.677E−04 | 0.914 | 343.492 | 0.003 | European |
| BP | UK Biobank | 336,683 | 155 | 9.052E−03 | 19.833 | − 5.716E−03 | 0.357 | 195.820 | 0.002 | European |
| Smoking | GSCAN | 607,291 | 155 | 5.018E−03 | 19.756 | 1.737E−02 | 0.127 | 190.689 | 0.018 | European |
No.SNPs number of single nucleotide polymorphism, MRC-IEU medical research council-integrative epidemiology unit, BMI body mass index, LDL-C low density lipoprotein-cholesterol, BP blood pressure, GSCAN GWAS and sequencing consortium of alcohol and nicotine use.