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. 2023 Jan 17;13:886. doi: 10.1038/s41598-022-27152-4

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Upregulation of EMT and angiogenesis in cluster 3 fibroblasts at day 4 post-wound in mice skin. (A) UMAP representing cells from 3 normal skin and 3 wounded skin samples at day 7 post-wound retrieved from GSE153596. (B) Expression level of Col1a1, Col1a2 and Mmp2. (C) UMAP plot representing cells from GSE153596 labeled using mutual nearest neighbor and label transfer (see methods) from GSE142471. (D) EMT score in cells from GSE142471. (E) Left panel represents EMT score in fibroblast clusters and other cell types. Right panel represents EMT score in cluster 3-like cells from GSE142471 in normal and wounded skin. (F) EMT score in cells from GSE153596. (G) Left panel represents EMT score in fibroblast clusters and other cell types. Right panel represents EMT score in cluster 3-like cells from GSE153596 in normal and wounded skin. (H-I) Angiogenesis score in cells from GSE142471 in all cells and in cluster 3 fibroblasts. (J-K) Angiogenesis score in cells from GSE153596 in all cells and in cluster 3 fibroblasts.