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. 2023 Jan 18;14:285. doi: 10.1038/s41467-023-35935-0

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — a TdT-mediated dUTP Nick-End Labeling (TUNEL) staining of the brains in healthy rats (n = 3) treated with Gd-FPFNP plus magnetic navigation (MN) or SNS plus MN at 21 days post intracarotid injection. Scale bars = 500 µm. The white rectangle indicates the site of the dentate gyrus (DG). The TUNEL images are representative of 3 images. b Body weight change of C57BL/6JNarl mice at 2 weeks post intracarotid injection with saline (control), Gd-FPFNP plus MN and SNS plus MN. The results were expressed as mean ± SD, n = 3 mice. c Fluoro-Jade C (FJC) staining of dentate gyrus area in brains of C57BL/6JNarl mice (n = 3) at 14 days after intracarotid injection with SNS + MN and Gd-FPFNP + MN (the white arrow indicates the neuropathic cells in positive control group). The FJC staining images are representative of 6 images. d H&E staining of major organs (heart, liver, spleen, lung, kidney, and brain) in C57BL/6JNarl mice (n = 3) at 14 days post intracarotid injection with Gd-FPFNP plus MN and SNS plus MN. Scale bar = 50 µm (heart, liver, kidney, and spleen) and 200 µm (lung and hippocampus cerebrum). The H&E staining images are representative of at least 6 images.