TABLE 1.
Characteristics of studies included in the meta-analysis.
| Author | Year | Disease | Ancestry | Case | Control | Age | Design | HWE | NOS | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| CC | CT | TT | CC | CT | TT | ||||||||
| Huang et al., (2022) | 2022 | IS | Asian | 94 | 72 | 32 | 101 | 62 | 5 | >18 | Case-control | 0.21 | 8 |
| Salomi et al., (2021) | 2021 | IS | Asian | 69 | 32 | 4 | 171 | 40 | 4 | 32.7±7.7 | Case-control | 0.36 | 8 |
| Cernera et al., (2021) | 2021 | IS | European | 64 | 140 | 76 | 138 | 206 | 85 | 8 | Case-control | 0.61 | 7 |
| Jiménez-González et al., (2021) | 2021 | IS | HLA | 35 | 105 | 38 | 60 | 83 | 40 | 34.1±5.4 | Case-control | 0.27 | 8 |
| Mazdeh et al., (2021) | 2021 | IS | ONR | 157 | 124 | 37 | 219 | 155 | 26 | 48±0.10 | Case-control | 0.84 | 7 |
| Hou et al., (2018) | 2018 | IS | Asian | 1063 | 793 | 138 | 1427 | 988 | 150 | 68.6±12.1 | Case-control | 0.22 | 9 |
| Mao and Han, (2018) | 2018 | IS | Asian | 73 | 189 | 27 | 82 | 100 | 16 | 68.42±13.26 | Case-control | 0.06 | 8 |
| Li et al., (2017) | 2017 | IS | Asian | 71 | 134 | 95 | 106 | 110 | 45 | 64.2±13.2 | Case-control | 0.08 | 8 |
| Kamberi et al., (2016) | 2017 | IS | European | 15 | 21 | 3 | 27 | 55 | 20 | 2.83–12.59 | Case-control | 0.40 | 8 |
| Ma et al., (2017) | 2017 | IS | Asian | 36 | 106 | 94 | 88 | 183 | 119 | Media 66.0 | Case-control | 0.27 | 7 |
| Lu et al., (2017) | 2017 | IS | Asian | 31 | 97 | 89 | 41 | 109 | 73 | NA | Case-control | 0.8 | 7 |
| Jiang et al., (2017) | 2017 | IS | Asian | 36 | 52 | 18 | 40 | 54 | 12 | 57.8±10.7 | Case-control | 0.33 | 8 |
| Kumar et al., (2016) | 2016 | IS | Asian | 161 | 84 | 5 | 183 | 65 | 2 | 52.83±12.5 | Case-control | 0.14 | 7 |
| Vijayan et al., (2016) | 2016 | IS | Asian | 164 | 35 | 1 | 185 | 8 | 0 | 57.74±13.84 | Case-control | 0.77 | 8 |
| Zhang et al., (2016) | 2016 | IS | Asian | 13 | 27 | 10 | 36 | 18 | 5 | NA | Case-Control | 0.23 | 8 |
| Herak et al., (2017) | 2017 | IS | European | 29 | 34 | 10 | 41 | 51 | 8 | 4.3(0.01–16.7) | Case-control | 0.15 | 7 |
| Ranellou et al., (2015) | 2015 | IS | European | 16 | 28 | 7 | 26 | 36 | 8 | 37.3±8.0 | Case-control | 0.40 | 8 |
| Wei et al., (2015) | 2015 | IS | Asian | 177 | 98 | 26 | 226 | 65 | 6 | 52.6±68.8 | Case-control | 0.60 | 8 |
| Luo et al., (2015) | 2015 | IS | Asian | 55 | 269 | 388 | 52 | 299 | 423 | 65.2±13.9 | Case-control | 0.93 | 8 |
| Lv et al., (2015) | 2015 | IS | Asian | 70 | 98 | 31 | 88 | 116 | 37 | 68.78 ± 10.63 | Case-control | 0.90 | 8 |
| Zhou et al., (2014) | 2014 | IS | Asian | 160 | 270 | 112 | 242 | 308 | 104 | Media 66 | Case-control | 0.72 | 8 |
| Atadzhanov et al., (2013) | 2014 | IS | African | 15 | 8 | 0 | 96 | 20 | 0 | 54 ± 16 | Case-control | 0.31 | 8 |
| Shi, (2014) | 2014 | IS | Asian | 18 | 36 | 31 | 33 | 35 | 14 | 77.89 ± 8.85 | Case-control | 0.38 | 8 |
| Supanc et al., (2014) | 2014 | IS | European | 41 | 78 | 36 | 75 | 59 | 16 | Middle-aged | Case-control | 0.40 | 8 |
| Fekih-Mrissa et al., (2013) | 2013 | IS | ONR | 35 | 43 | 6 | 60 | 35 | 5 | 56.06 ± 12.5 | Case-control | 0.97 | 8 |
| Zhang and Guo, (2012) | 2012 | IS | Asian | 9 | 19 | 12 | 10 | 20 | 10 | 39.25 ± 4.08 | Case-control | 1.00 | 8 |
| Djordjevic et al., (2012) | 2012 | IS | ONR | 24 | 50 | 6 | 33 | 54 | 13 | 6.7 ± 4.9 | Case-control | 0.21 | 8 |
| Djordjevic et al., (2012) | 2012 | IS | ONR | 39 | 23 | 11 | 59 | 47 | 14 | 40.3 ± 11.6 | Case-control | 0.33 | 88 |
| Somarajan et al., (2011) | 2011 | IS | Asian | 137 | 65 | 5 | 129 | 54 | 5 | 54 ± 15.9 | Case-control | 0.82 | 8 |
| Mohamed et al., (2011) | 2011 | IS | Asian | 69 | 60 | 21 | 85 | 48 | 9 | 61.0 ± 10.1 | Case-control | 0.53 | 8 |
| Hultdin et al., (2011) | 2011 | IS | ONR | 172 | 114 | 27 | 401 | 306 | 59 | 55.0 ± 8.0 | Nested | 0.95 | 8 |
| Salem-Berrabah et al., (2010) | 2011 | IS | ONR | 33 | 15 | 2 | 57 | 35 | 5 | Mean 57.62 | Case-control | 0.90 | 7 |
| Isordia-Salas et al., (2010) | 2010 | IS | HLA | 35 | 105 | 38 | 60 | 83 | 40 | 33.1 ± 5.8 | Case-control | 0.27 | 8 |
| Giusti et al., (2010) | 2010 | IS | European | 130 | 240 | 131 | 572 | 529 | 110 | Media 44.0 | Case-control | 0.437 | 7 |
| Tatarskyy et al., (2010) | 2010 | IS | ONR | 73 | 87 | 23 | 50 | 45 | 5 | 64.6 ± 9.1 | Case-control | 0.20 | 8 |
| Al-Allawi et al., (2009) | 2009 | IS | ONR | 26 | 30 | 14 | 27 | 20 | 3 | Media 60 | Case-control | 0.78 | 7 |
| Sun et al., (2009) | 2009 | IS | Asian | 45 | 36 | 38 | 49 | 37 | 10 | >60 | Case-control | 0.45 | 7 |
| Sabino et al., (2009) | 2009 | IS | HLA | 12 | 9 | 0 | 24 | 12 | 1 | 33.3 ± 16.3 | Case-control | 0.73 | 7 |
| Biswas et al., (2009) | 2009 | IS | Asian | 24 | 32 | 2 | 48 | 10 | 0 | <15 | Case-control | 0.47 | 7 |
| Biswas et al., (2009)) | 2009 | IS | Asian | 67 | 49 | 4 | 90 | 30 | 0 | Young | Case-control | 0.12 | 8 |
| (Morita et al., 2009) | 2009 | IS | European | 5 | 6 | 4 | 48 | 37 | 5 | Children | Case-control | 0.53 | 7 |
| Herak et al., (2009) | 2009 | IS | European | 11 | 17 | 5 | 46 | 56 | 10 | Children | Case-control | 0.22 | 7 |
| Goracy et al., (2009) | 2009 | IS | European | 65 | 69 | 18 | 83 | 46 | 6 | 66.7 ± 12.5 | Case-control | 0.91 | 8 |
| Zak et al., (2009) | 2009 | IS | European | 25 | 30 | 9 | 32 | 25 | 2 | Children | Case-control | 0.27 | 8 |
| Djordjevic et al., (2009) | 2009 | IS | ONR | 9 | 16 | 1 | 23 | 22 | 5 | Children | Case-control | 0.94 | 8 |
| Almawi et al., (2009) | 2009 | IS | ONR | 54 | 26 | 38 | 90 | 26 | 4 | NA | Case-control | 0.23 | 7 |
| Sawula et al., (2009) | 2009 | IS | European | 70 | 50 | 8 | 35 | 19 | 5 | 18–101 | Case-control | 0.31 | 8 |
| Yue et al., (2010) | 2009 | IS | Asian | 8 | 19 | 35 | 14 | 11 | 5 | 67 ± 9 | Case-control | 0.29 | 8 |
| Celiker et al., (2009) | 2009 | IS | ONR | 158 | 4 | 0 | 63 | 37 | 6 | Mean 69.8 | Case-control | 0.85 | 8 |
| Shi et al., (2008) | 2008 | IS | Asian | 23 | 45 | 29 | 20 | 45 | 34 | Young | Case-control | 0.07 | 8 |
| Moe et al., (2008) | 2008 | IS | Asian | 73 | 36 | 11 | 136 | 68 | 3 | 62.5 ± 1.1 | Case-control | 0.09 | 8 |
| Gao et al., (2008) | 2008 | IS | Asian | 4 | 20 | 18 | 6 | 11 | 13 | ≤45 | Case-control | 0.22 | 8 |
| Zhang et al., (2008) | 2008 | IS | Asian | 49 | 116 | 80 | 74 | 140 | 68 | 63.7 ± 10.4 | Case-control | 0.91 | 8 |
| Berge et al., (2007) | 2007 | IS | European | 29 | 125 | 182 | 25 | 141 | 163 | Old | Case-control | 0.47 | 7 |
| Nan et al., (2007) | 2007 | IS | Asian | 14 | 55 | 31 | 28 | 53 | 19 | <45 | case-control | 0.49 | 8 |
| Kim et al., (2007) | 2007 | IS | Asian | 81 | 113 | 43 | 66 | 119 | 38 | 61.18 ± 11.09 | Case-control | 0.21 | 8 |
| Komitopoulou et al., (2006) | 2006 | IS | European | 36 | 46 | 8 | 46 | 39 | 18 | 5.55 ± 0.48 | Case-control | 0.06 | 8 |
| Sazci et al., (2006) | 2006 | IS | ONR | 42 | 41 | 9 | 115 | 119 | 25 | 53.45 ± 9.21 | Case-control | 0.47 | 8 |
| Li et al., (2006) | 2006 | IS | Asian | 235 | 184 | 35 | 190 | 128 | 16 | 65.20 ± 12.75 | Case-control | 0.34 | 8 |
| Dikmen et al., (2006) | 2006 | IS | ONR | 75 | 57 | 14 | 32 | 21 | 2 | 63.4 ± 0.87 | Case-control | 0.52 | 8 |
| Gao et al., (2006) | 2006 | IS | Asian | 30 | 49 | 21 | 32 | 44 | 24 | 61.08 ± 10.77 | Case-control | 0.25 | 8 |
| Yanqun et al., (2006) | 2006 | IS | Asian | 49 | 73 | 40 | 49 | 41 | 10 | 55 ± 6 | Case-control | 0.74 | 7 |
| Hermans et al., (2006) | 2006 | IS | ONR | 4 | 13 | 6 | 62 | 58 | 22 | 71.7 ± 9.3 | Case-control | 0.18 | 9 |
| Pezzini et al., (2005) | 2005 | IS | European | 46 | 83 | 34 | 60 | 75 | 23 | 35.0 ± 7.5 | Case-control | 0.96 | 9 |
| En et al., (2005) | 2005 | IS | Asian | 88 | 43 | 5 | 51 | 17 | 2 | 65 ± 10 | Case-control | 0.69 | 8 |
| Yan et al., (2006) | 2005 | IS | Asian | 34 | 24 | 3 | 37 | 17 | 3 | Old | Case-control | 0.58 | 8 |
| Jinhuan et al., (2005) | 2005 | IS | Asian | 55 | 28 | 4 | 53 | 24 | 3 | Mean 65 | Case-control | 0.89 | 8 |
| Alluri et al., (2005) | 2005 | IS | ONR | 47 | 21 | 1 | 48 | 1 | 0 | 7–78 | Case-control | 0.94 | 8 |
| Kawamoto et al., (2005) | 2005 | IS | Asian | 33 | 43 | 21 | 91 | 110 | 40 | 78 ± 8.3 | Case-control | 0.49 | 8 |
| Yi et al., (2005) | 2005 | IS | Asian | 27 | 42 | 9 | 22 | 25 | 3 | 68.3 ± 7.6 | Case-control | 0.23 | 8 |
| Lingling et al., (2004) | 2004 | IS | Asian | 26 | 18 | 3 | 12 | 15 | 5 | 67.16 ± 10.11 | Case-control | 0.93 | 8 |
| Choi et al., (2003) | 2003 | IS | Asian | 62 | 97 | 36 | 73 | 100 | 25 | 61.4 ± 10.9 | Case-control | 0.30 | 7 |
| Jin et al., (2004) | 2003 | IS | Asian | 21 | 59 | 14 | 40 | 49 | 11 | 69.68 ± 8.9 | Case-control | 0.48 | 8 |
| Jin et al., (2004) | 2003 | IS | Asian | 15 | 23 | 21 | 15 | 11 | 7 | NA | Case-control | 0.09 | 7 |
| Yan et al., (2003) | 2003 | IS | Asian | 55 | 28 | 4 | 53 | 24 | 3 | 66.13 ± 12.54 | Case-control | 0.89 | 8 |
| Li et al., (2002) | 2002 | IS | Asian | 58 | 65 | 20 | 97 | 49 | 8 | 40–90 | Case-control | 0.58 | 8 |
| Chuanqing et al., (2002) | 2002 | IS | Asian | 24 | 35 | 10 | 25 | 35 | 7 | 62.3 ± 12.9 | Case-control | 0.30 | 8 |
| Wenping et al., (2003) | 2002 | IS | Asian | 8 | 34 | 19 | 25 | 46 | 15 | 61–79 | Case-control | 0.43 | 8 |
| Huang et al., (2002) | 2002 | IS | Asian | 11 | 25 | 13 | 16 | 24 | 10 | 55.5 ± 13.0 | Case-control | 0.85 | 8 |
| Guangsen and Chongwen, (2002) | 2002 | IS | Asian | 40 | 47 | 15 | 37 | 47 | 16 | 65 | Case-control | 0.87 | 8 |
| Akar et al., (2001) | 2001 | IS | ONR | 24 | 18 | 4 | 39 | 23 | 6 | Children | Case-control | 0.34 | 7 |
| Wu et al., (2001) | 2001 | IS | Asian | 23 | 40 | 14 | 92 | 113 | 24 | 61.4 ± 6.8 | Case-control | 0.21 | 8 |
| Yaqin et al., (2001) | 2000 | IS | Asian | 15 | 23 | 21 | 15 | 11 | 7 | NA | Case-control | 0.09 | 7 |
| Zheng et al., (2000) | 2000 | IS | Asian | 43 | 62 | 10 | 62 | 45 | 15 | Mean 59 | Case-control | 0.14 | 8 |
| Cumming et al., (1999) | 1999 | IS | ONR | 41 | 6 | 1 | 42 | 6 | 0 | 7–36 | Case-control | 0.64 | 7 |
| Harmon et al., (1999) | 1999 | IS | European | 74 | 73 | 27 | 86 | 78 | 19 | >60 | Case-control | 0.83 | 7 |
| Gaustadnes et al., (1999) | 1999 | IS | European | 97 | 88 | 22 | 545 | 449 | 90 | 25–68 | Case-control | 0.85 | 8 |
| Akar et al., (1999) | 1999 | IS | ONR | 14 | 10 | 4 | 63 | 37 | 6 | Children | Case-control | 0.85 | 8 |
| Press et al., (1999) | 1999 | IS | ONR | 72 | 85 | 10 | 50 | 57 | 8 | 65 ± 8 | Case-control | 0.12 | 8 |
| Lalouschek et al., (1999) | 1999 | IS | ONR | 35 | 37 | 9 | 32 | 40 | 9 | 64.76 ± 13.2 | Case-control | 0.50 | 8 |
| Xinliang et al., (1999) | 1999 | IS | Asian | 10 | 45 | 25 | 58 | 32 | 20 | 60.2 ± 6.1 | Case-control | 0.48 | 8 |
| De Stefano et al., (1998) | 1998 | IS | European | 28 | 27 | 17 | 65 | 98 | 35 | Mean 33.9 | Case-control | 0.85 | 8 |
| Kostulas et al., (1998) | 1998 | IS | ONR | 50 | 40 | 10 | 50 | 40 | 10 | NA | Case-control | 0.63 | 7 |
| Salooja et al., (1998) | 1998 | IS | European | 81 | 76 | 16 | 114 | 107 | 21 | 68 (22–94) | Case-control | 0.56 | 8 |
| Nakata et al., (1998) | 1998 | IS | Asian | 19 | 23 | 6 | 35 | 51 | 19 | 30–80 | Case-control | 0.96 | 8 |
| Markus et al., (1997) | 1997 | IS | European | 162 | 146 | 37 | 76 | 63 | 22 | 65.7 (10.5) | Case-control | 0.13 | 7 |