TABLE 2.
Pooled odds ratios (ORs) and 95% confidence intervals (CIs) of the association between C677T polymorphism and stroke in the dominant model.
| Model | OR (95% CI) | PZ | I2 | PH |
|---|---|---|---|---|
| Dominant | ||||
| All IS | 1.47 (1.33–1.61) | <0.001 a | 69.9% | <0.001 |
| Ancestry | ||||
| Asian | 1.59 (1.41–1.80) | <0.001 a | 67.2% | <0.001 |
| European | 1.35 (1.10–1.65) | 0.004 | 69.9% | <0.001 |
| African | 2.56 (0.96–6.85) | 0.061 | — | — |
| Hispanic or Latin American | 1.93 (1.39–2.67) | <0.001 a | 0.0% | 0.824 |
| Other and not reported ancestries | 1.20 (0.91–1.57) | 0.190 | 76.4% | <0.001 |
| Age | ||||
| Young | 1.46 (1.12–1.91) | 0.005 | 52.2% | 0.012 |
| Middle-aged | 1.59 (1.33–1.90) | <0.001 a | 69.8% | <0.001 |
| Elderly | 1.34 (1.17–1.53) | <0.001 a | 71.3% | <0.001 |
| NA | 1.77 (1.30–2.41) | <0.001 a | 69.3% | <0.001 |
Bonferroni correction for multiple testing was applied (p-value threshold, 0.001);
PZ, p-value for the Z-test; PH, p-value for heterogeneity;
a
Association was still significant after Bonferroni correction for multiple testing.