TABLE 4.
Pooled odds ratios (ORs) and 95% confidence intervals (CIs) of the association between C677T polymorphism and stroke in the heterozygous model.
| Model | OR (95% CI) | PZ | I2 | PH |
|---|---|---|---|---|
| Heterozygote | ||||
| All IS | 1.36 (1.24–1.48) | <0.001 a | 60.4% | <0.001 |
| Ancestry | ||||
| Asian | 1.46 (1.30–1.63) | <0.001 a | 58.2% | <0.001 |
| European | 1.27 (1.08–1.51) | 0.005 | 50.4% | 0.006 |
| African | 2.56 (0.96–6.85) | 0.061 | — | — |
| Hispanic or Latin American | 2.09 (1.50–2.95) | <0.001 a | 0.0% | 0.825 |
| Other and not reported ancestries | 1.10 (0.86–1.40) | 0.453 | 67.6% | <0.001 |
| Age | ||||
| Young | 1.44 (1.13–1.84) | 0.003 | 38.7% | 0.069 |
| Middle-aged | 1.50 (1.27–1.78) | <0.001 a | 62.5% | <0.001 |
| Elder | 1.23 (1.08–1.40) | 0.001 a | 62.8% | 0.001 |
| NA | 1.48 (1.14–1.92) | 0.003 | 50.2% | 0.020 |
Bonferroni correction for multiple testing was applied (p-value threshold 0.001);
PZ, p-value for the Z-test; PH, p-value for heterogeneity;
a
Association was still significant after Bonferroni correction for multiple testing.