TABLE 5.
Pooled odds ratios (ORs) and 95% confidence intervals (CIs) of the association between C677T polymorphism and stroke in the homozygous model.
| Model | Or (95% CI) | PZ | I2 | PH |
|---|---|---|---|---|
| Homozygote | ||||
| All IS | 1.82 (1.58–2.11) | <0.001 a | 64.2% | <0.001 |
| Ancestry | ||||
| Asian | 1.98 (1.66–2.37) | <0.001 a | 59.4% | <0.001 |
| European | 1.65 (1.14–2.39) | 0.008 | 79.3% | <0.001 |
| African | — | — | — | — |
| Hispanic or Latin American | 1.60 (1.05–2.46) | 0.030 | 0.0% | 0.863 |
| Other and not reported ancestries | 1.59 (1.09–2.32) | 0.017 | 56.2% | 0.001 |
| Age | ||||
| Young | 1.43 (0.88–2.33) | 0.146 | 55.6% | 0.006 |
| Middle-aged | 1.92 (1.45–2.53) | <0.001 a | 62.7% | <0.001 |
| Elder | 1.74 (1.44–2.11) | <0.001 a | 62.3% | <0.001 |
| NA | 2.45 (1.47–4.01) | 0.001 a | 69.1% | <0.001 |
Bonferroni correction for multiple testing was applied (p-value threshold 0.001);
PZ, p-value for the Z-test; PH, p-value for heterogeneity;
a
Association was still significant after Bonferroni correction for multiple testing.