Table 2:

Baseline study characteristics of studies identified in the systematic review

Author, year	Country	Study Type	Number of patients	Mean age (years)	Inclusion Criteria	Exclusion criteria	Mean follow-up
Cross HM, et al. 2013 *	South Africa	Prospective cohort	111	29.6	HIV infected, age 18 to 35, completed at least 7 years of school	Uncontrolled medical conditions, psychiatric or neurologic condition, substance or alcohol abuse disorder, or previous moderate to severe head injury	52 weeks
Cysique LA, et al. 2009	United States	Prospective cohort	37	39.7	HIV infected, ART naïve or ART treatment failure (defined as HIV RNA >5,000 copies/mL), HAND at baseline	History of neurologic disease unrelated to HIV, psychotic psychiatric disease, drug abuse disorder within last 6 months, history of traumatic brain injury with loss of consciousness for greater than 1 hour	48 weeks
Ellis RJ, et al. 2014 *	United States	Randomized controlled trial	59	44.9	HIV infected, current symptoms of HAND, on stable ARV for at least 8 weeks, and under consideration to change ARV regimen	Active opportunistic infection, neuropsychiatric (NP) impairment due to a disorder other than HIV, substance use disorder as diagnosed by DSM-IV within past 12 months, active severe psychiatric disorder, positive urine drug screening	16 weeks
Marra CM, et al. 2009	United States	Prospective cohort	79	39	HIV infected, CD4+ count <200/μL with HIV RNA >2000 copies/mL or HIV RNA >50,000 regardless of CD4+ count, either initiating cART or changing therapy	Not on a cART regimen with ≥3 agents	52 weeks
Perez-Valero I, et al. 2014 *	Spain	Prospective cohort	134	44.6	HIV infected, undetectable viral load for ≥1 year, treated with either darunavir/r or lopinavir/r as monotherapy or with emtricitabine-tenofovir as triple therapy	Non-Spanish speaking	52 weeks
Smurzynski M, et al. 2011	United States	Prospective cohort	2,636	40	HIV infected, either treatment naïve or experienced, included in AIDS Clinical Trials Group Longitudinal Linked Randomized TRIAL (ALLRT) cohort	Factors that would compromise the ability to comply with scheduled visits	4.7 years
Tozzi V, et al. 2009	Italy	Prospective cohort	185	39.3	HIV infected, previous symptoms of HAND, symptomatic HIV, CD4+ count <200/μL	Current or past opportunistic infection, tumor of the CNS, non-HIV related neuropsychiatric illness, current illicit drug use, or use of sedative hypnotics	39 months
Valcour VG, et al. 2015 *	Thailand	Randomized controlled trial	62	27	HIV infected	CNS opportunistic infection	24 weeks

^*Included in quantitative meta-analysis