Table A2:

EMBASE Search Strategy

ID	Search	Hits
1	(‘haart’/exp OR ‘haart’ OR ‘cart’ OR ‘highly active antiretroviral therapy’/exp OR ‘highly active antiretroviral therapy’ OR ‘combined antiretroviral therapy’/exp OR ‘combined antiretroviral therapy’ OR ‘hiv therapy’ OR ‘antiretroviral therapy’/exp OR ‘antiretroviral therapy’)	96,887
2	(‘cpe’ OR ‘cns penetration effectiveness’ OR ‘cns penetration effectiveness’)	9,309
3	1 AND 2	136
4	3 NOT ‘prevalence’	106
5	(‘cognitive function’ OR ‘cognition’ OR ‘neurocognitive impairment’ OR ‘npz4’ OR ‘gds’)	378,794
6	4 AND 5	46