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. Author manuscript; available in PMC: 2023 Oct 18.
Published in final edited form as: J Immunol. 2022 Aug 1;209(3):569–581. doi: 10.4049/jimmunol.2200065

Figure 1: RNA-Seq reveals the gene encoding Icam1 was rapidly upregulated in response to IL-1β in human islets and the 832/13 rat β-cell line.

Figure 1:

Clustered heatmap of the top 50 most up-regulated and down-regulated genes in human islets (A) and 832/13 rat insulinoma cells (B) exposed to IL-1β for 3 h (selected by magnitude of fold-change). Treatment conditions across replicates are indicated at the top of the heatmap and genes are indicated in rows. Gene expression signals were row-normalized with higher gene expression is expressed in shades of red and lower expression in shades of blue. The blue arrow indicates the Icam1 gene. C. Pathway enrichment analysis of human islets and 832/13 rat β-cells as determined via GSEA. The top enriched pathways from each study (FDR≤5%) were compared via a Venn analysis. Numbers in parentheses refer to the number of significantly enriched pathways in each set. Pathways identified in common in both species are listed in bulleted format. NT = no treatment; IL = IL-1β- treated.