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. Author manuscript; available in PMC: 2023 Oct 18.
Published in final edited form as: J Immunol. 2022 Aug 1;209(3):569–581. doi: 10.4049/jimmunol.2200065

Figure 2. Expression of Icam1 is inducible ex vivo in mouse, rat, and human islets and in vivo in both C57BL/6J and NOD mice.

Figure 2.

A. Human islets (n=3) were untreated (NT) or stimulated with 10 ng/mL IL-1β for the indicated times. B. Rat islets (n=3) were NT or stimulated with 10 ng/mL IL-1β for the indicated times. C. Mouse islets (n=3) were NT or stimulated for 3 h with 10 ng/mL IL-1β. D. Formalin-fixed paraffin-embedded (FFPE) pancreatic tissue was sectioned and stained for ICAM-1 (pink) and glucagon (brown) in 12 week old male C57BL/6J mice injected with either saline control or IL-1β (1 μg/kg body weight). E. Icam1 mRNA abundance in islets isolated from 12 week old normoglycemic male (n=3) and female (n=7) NOD mice. F. Icam1 expression levels in islets isolated from 16 week old female control (n=10) or hyperglycemic (n=9) NOD mice. The transcript data (A-C, E-F) are shown as means ± SEM. ***, p < 0.001; **, p < 0.01; *, p < 0.05. p values are vs. respective NT controls.