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. 2022 Dec 8;10:rbac099. doi: 10.1093/rb/rbac099

Table 3.

Applications, manufacturing method and properties of MPs based on proteins used in pulmonary drug delivery

Protein API Manufacturing method MPs properties Aerodynamic properties References
Silk fibroin Cisplatin (lung cancer) Spray freeze-drying Size (D50): 5.20 ± 0.69 μm FPF: 62.25% Kim et al. (2015) [75]
Silk fibroin Ciprofloxacin (non-cystic fibrosis bronchiectasis) Spray drying

  • Size (D50): 2.95 ± 0.05–4.55 ± 0.10

  • Morphology: spherical shape with shrinkage surface

  • (depending on drug loading)

  • MMAD: 3.75 ± 0.03–4.66 ± 0.17 µm

  • ED: 94.49 ± 0.84–98.10 ± 1.27%

  • FPF: 36.77 ± 3.86–45.04 ± 0.84%

  • GSD: 1.66 ± 0.10–4.23 ± 0.16

  • (depending on drug loading)

 Liu et al. (2019) [76]
Polylysine + dextrin Indomethacin (rheumatoid arthritis) Spray-drying

  • Size (D50): 5.99 ± 0.27 µm,

  • Morphology:

  • non-porous

  • LE: 20 ± 1%

  • D ae: 4.79 µm,

  • FPF: 51.55 ± 0.37%

 Ceschan et al. (2015) [77]

MPs, microparticles; MMAD, mass median aerodynamic diameter; ED, emitted dose; GSD, geometric standard deviation; FPF, fine particle fraction.