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. 2022 Dec 8;10:rbac099. doi: 10.1093/rb/rbac099

Table 6.

Applications, manufacturing method and properties of solid lipid nanoparticles assemblies

Lipid API Manufacturing method MPs properties Aerodynamic properties References
Stearic acid Rifampicin (tuberculosis) Hot emulsification/freeze-drying

  • Morphology: irregular

  • Size (DLS): 0.6–1.7 µm

  • LE: 11.8–15.9%

 – Maretti et al. (2016) [136]
Glyceryl behenate Ethambutol hydrochloride (tuberculosis) Hot emulsification/spray drying

  • Morphology: spherical, rather smooth

  • Size (measurement based on SEM images): 1–2 µm

  • MMAD: 4.15–5.63 µm

  • FPF: 23.98 ± 0.38–30.91 ± 0.77%

 Nemati et al. (2019) [139]
Glyceryl distearate Salmeterol Xinafoate (COPD) Hot emulsification/coating with sodium alginate Size (DLS): 3.3 µm

  • MMAD: 3.65 ± 1.29 µm

  • FPF: 75 ± 7%

 Amore et al. (2019) [140]

MPs, microparticles; LE, loading efficiency; MMAD, mass median aerodynamic diameter; FPF, fine particle fraction; DLS, dynamic light scattering.