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. 2023 Jan 17;13:3. doi: 10.1186/s13550-023-00951-0

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© The Author(s) 2023

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — Representative ¹⁸F-NaF PET/CT imaging of the lower extremities in a patient with PAD and DM. Fused coronal ¹⁸F-NaF PET/CT imaging of both lower extremities demonstrated heterogenous macrocalcification detected by CT imaging and heterogenous arterial uptake of ¹⁸F-NaF detected by PET. Focused axial images at the level of the knee further revealed that increased ¹⁸F-NaF uptake was localized to arterial regions undergoing active microcalcification and were not yet fully detectable by CT imaging (denoted by white arrows)